Sturtevant (1913) noted that the order of genes on the X chromosome of Drosophila could be deduced from recombination frequencies. These recombination frequencies were approximately additive, and Sturtevant considered this property to be fundamental. He recognized departures from additivity as due to double crossing-over, which he took to be a deviation from his null hypothesis of additivity. By the time Sturtevant had completed his thesis (1915), he and Muller (1916) appeared to have recognized that a more useful null hypothesis supposed that multiple exchanges occur at random with respect to each other. The near additivity of X-chromosome recombination frequencies represented a rather severe deviation from this new null hypothesis. The deviation was called "interference." In a multifactor cross, interference is usually expressed in terms of the (inclusive) coefficient of coincidence, which is the ratio of observed double crossovers to the number of double crossovers expected on the null hypothesis of...
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Lande et al. (1993) studied this question.