December 1, 2005The International Journal of Artificial Organs
Do We Have Reliable Biochemical Markers to Predict the Outcome of Critical Illness?
Key result
Biochemical markers for predicting ICU mortality remain elusive and unvalidated in large populations due to the complex and heterogeneous processes underlying critical illness.
Why the study?
Do biochemical markers reliably predict the outcome of critical illness?
Population
Critically ill patients (ICU patients)
Design
Review
Authors
Discussion
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Member takes
Implication
No biochemical marker should guide ICU mortality prediction; leaves open development of integrated multifactorial models.
Structured PICO
Do biochemical markers reliably predict the outcome of critical illness?
P
Population
Critically ill patients (ICU patients)
E
Exposure
Biochemical markers reflecting inflammation, immune dysfunction, impaired tissue oxygenation, and endocrine alterations
O
Outcome
Outcome prediction / ICU mortality
A simple biochemical predictor of ICU mortality is unlikely to be found due to the complexity and heterogeneity of critical illness, necessitating more sophisticated future prognostic models.
Limitations
- None of the biochemical parameters have been validated in large populations of unselected ICU patients.
Cite This Study
Schetz et al. (2005) conducted a review in Critical illness. Biochemical markers was evaluated on ICU mortality. Biochemical markers for predicting ICU mortality remain elusive and unvalidated in large populations due to the complex and heterogeneous processes underlying critical illness.