Lambert-Eaton myasthenic syndrome in association with Sjögren’s syndrome: a case report

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Key Points

This report aims to illustrate the clinical presentation and diagnostic process for a patient with Lambert-Eaton myasthenic syndrome linked to Sjögren’s syndrome.
Clinical observations of muscle weakness, gait impairment, and reflexes
Electrophysiological studies, including nerve conduction and needle EMG
Laboratory tests including cerebrospinal fluid analysis and autoantibody detection
Patient exhibited significant proximal muscle weakness with lower limb predominance and areflexia.
Nerve conduction studies showed low-amplitude compound muscle action potentials and high-frequency stimulation increment.
Serum analysis revealed elevated anti-VGCCs P/Q-type antibodies, supporting the diagnosis of Lambert-Eaton myasthenic syndrome.

Case report details diagnostic challenges in Lambert-Eaton myasthenic syndrome due to Sjögren’s syndrome, suggesting complex interactions.

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Potužník et al. (2026) studied this question.

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