Key result
High SHR and TyG index linked to ~152% greater risk of adverse renal outcomes.
Why the study?
Diabetic kidney disease is a major complication of T2DM and leading cause of ESKD, but the association of stress hyperglycemia ratio and TyG index with renal outcomes during finerenone therapy was unknown.
Do higher stress hyperglycemia ratio (SHR) and triglyceride-glucose (TyG) index predict worse renal outcomes in adults with diabetic kidney disease initiating finerenone therapy?
Population
387 adults with DKD and CKD stages 1–4 initiating finerenone therapy
Comparison
Higher vs lower tertiles of baseline SHR and TyG index
Design
Retrospective cohort study
Authors
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May flag higher-risk DKD patients on finerenone; hypothesis-generating and requires prospective validation before clinical use.
Cohort (n=387)
No
Do higher stress hyperglycemia ratio (SHR) and triglyceride-glucose (TyG) index predict worse renal outcomes in adults with diabetic kidney disease initiating finerenone therapy?
Hazard Ratio: 2.52 (95% CI 1.48–4.29)
p-value: p=0.001
Higher stress hyperglycemia ratio and triglyceride-glucose index are associated with worse renal outcomes and an attenuated response to finerenone in patients with diabetic kidney disease.
Chen et al. (2026) conducted a cohort in Diabetic kidney disease (n=387). Stress hyperglycemia ratio (SHR) vs. Lowest tertile (T1) was evaluated on Composite of sustained ≥40% eGFR decline or progression to ESKD (HR 2.52, 95% CI 1.48-4.29, p=0.001). Higher baseline stress hyperglycemia ratio (SHR) and triglyceride-glucose (TyG) index were associated with worse renal outcomes, with the highest SHR tertile having a HR of 2.52 for the composite renal endpoint.
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