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Investigates the link between serum ghrelin, NLRP3, and diabetic retinopathy progression, suggesting a role in pathogenesis.
PURPOSE: To investigate the serum levels of ghrelin and Nod-like receptor protein 3 (NLRP3) in patients with diabetic retinopathy (DR) and evaluate their correlation with DR progression. METHODS: Thirty-seven patients with DR admitted to the First People's Hospital of Xianyang between April 2024 and April 2025 were enrolled and classified into non-proliferative DR (NPDR) and proliferative DR (PDR) subgroups based on fundus lesion severity. Fifty-three patients with simple cataracts served as controls. Serum levels of ghrelin and NLRP3 were measured using enzyme-linked immunosorbent assay, and their relationship with systemic indicators was analyzed. CONCLUSIONS: Decreased serum ghrelin and elevated serum NLRP3 levels in patients with DR suggest that ghrelin and NLRP3 are involved in DR pathogenesis.
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Lu et al. (2026) studied this question.
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