Uncovers thalamic circuits' role in modulating dopamine for safety behaviors, suggesting new intervention pathways.
Avoiding danger even when competing goals are imminent supports survival, yet the mechanisms orchestrating this behavioral override remain unclear. Macdonald and colleagues1 describe a thalamostriatal microcircuit that modulates terminal dopamine release, bypassing canonical midbrain dopamine circuitry to prioritize safety.
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Clarke et al. (2026) studied this question.
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