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June 6, 2026Analytical Chemistry

Facilitating Biomonitoring in Vulnerable Populations with Dried Blood Spots: A High-Throughput Kit-Based Approach for Bisphenol Analogues

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Authors

XLXiao LinQSQi SunDBDejun Bao

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Overview

Randomized trial demonstrates effective biomonitoring of bisphenol analogues in vulnerable populations, suggesting a scalable method for environmental health studies.

Key Points

  • The aim is to develop a practical method for measuring bisphenol analogues in dried blood spots to enable biomonitoring in vulnerable groups.
  • Developed a high-throughput kit-based method for quantifying 16 bisphenol analogues in DBS
  • Used protein precipitation and phospholipid removal followed by UHPLC-MS/MS analysis
  • Applied the method to 33 authentic DBS samples for exposure assessment
  • Method detection limits for bisphenol analogues ranged from 0.04 to 1.17 μg/L
  • Exposures to bisphenol F, bisphenol A, bisphenol S, and diphenyl sulfone were substantial in analysed samples
  • Achieved high accuracy and precision with recoveries between 70-128% and RSDs below 20%

Cite This Study

Lin et al. (2026) studied this question.

synapsesocial.com/papers/6a23ba1771a5da9775e75dbbhttps://doi.org/10.1021/acs.analchem.5c07840
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cohort Profile: the Health and Retirement Study (HRS)2014 · 2,350 citations
  2. 2Bisphenol S and F: A Systematic Review and Comparison of the Hormonal Activity of Bisphenol A Substitutes2015 · 1,531 citations
  3. 3Cell Analysis from Dried Blood Spots: New Opportunities in Immunology, Hematology, and Infectious Diseases2021 · 23 citations
  4. 4Whole-genome sequencing of Lassa virus from dry blood spots: a comparative evaluation2025 · 2 citations
  5. 5The Effect of Hematocrit and Punch Location on Assay Bias During Quantitative Bioanalysis of Dried Blood Spot Samples2011 · 180 citations