Key result
Milrinone increased cardiac output (P<0.0001) and stroke volume (P=0.03) and decreased vascular resistance (P<0.0001) and systolic blood pressure (P=0.008) more potently than dobutamine.
Why the study?
Does milrinone improve physiological parameters compared to dobutamine in patients with subarachnoid hemorrhage requiring a pulmonary artery catheter?
Population
11 patients with subarachnoid hemorrhage requiring a pulmonary artery catheter
Comparison
Milrinone vs Dobutamine
Design
Cohort
Authors
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Milrinone may provide superior hemodynamics versus dobutamine in neurogenic stunned myocardium; leaves open need for randomized outcome trials.
Observational (n=11)
Does milrinone improve physiological parameters compared to dobutamine in patients with subarachnoid hemorrhage requiring a pulmonary artery catheter?
p-value: p=<0.0001
Milrinone is more effective at increasing cardiac output but decreases vascular resistance and blood pressure compared to dobutamine in patients with subarachnoid hemorrhage.
Naidech et al. (2005) conducted an observational in Subarachnoid hemorrhage (n=11). Milrinone vs. Dobutamine was evaluated on Physiological dose response (cardiac output, stroke volume, vascular resistance, systolic blood pressure) (p=<0.0001). Milrinone increased cardiac output (P<0.0001) and stroke volume (P=0.03) and decreased vascular resistance (P<0.0001) and systolic blood pressure (P=0.008) more potently than dobutamine.
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