Pd-Catalyzed Regioselective Synthesis of Allenyl Sulfones via Sulfinate-Enabled Isomerization

Shengming Ma; Shiwen Fan; Zhaoqiang Chen; Wenya Li; Hui Qian

doi:10.1039/d6cc02404a

January 1, 2026Chemical Communications

Pd-Catalyzed Regioselective Synthesis of Allenyl Sulfones via Sulfinate-Enabled Isomerization

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Key Points

The aim is to develop a Pd-catalyzed method for synthesizing tetrasubstituted allenyl sulfones via a novel coupling strategy.
Utilized excess sulfinate as both coupling partner and isomerization promoter.
Employed Pd catalysts in the synthesis process.
Focused on regioselectivity in the formation of products.
Achieved efficient synthesis of tetrasubstituted allenyl sulfones.
Demonstrated significant regioselectivity using the sulfinate approach.
Enabled a unique strategy for C-S bond formation through this methodology.

Implication

Experimental synthesis demonstrates regioselective formation of allenyl sulfones using sulfinate for isomerization.

Abstract

An efficient Pd-catalyzed C-S coupling strategy for the synthesis of tetrasubstituted allenyl sulfones has been developed. Excess sulfinate uniquely acts as both coupling partner and isomerization promoter, driving the in...

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Cite This Study

Ma et al. (2026) studied this question.

synapsesocial.com/papers/6a23bad471a5da9775e76760 https://doi.org/10.1039/d6cc02404a

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Pd-Catalyzed Regioselective Synthesis of Allenyl Sulfones via Sulfinate-Enabled Isomerization

Key Points

Implication

Abstract

Discussion

Cite This Study

Pd-Catalyzed Regioselective Synthesis of Allenyl Sulfones via Sulfinate-Enabled Isomerization

Key Points

Implication

Abstract

Discussion

Cite This Study

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