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June 6, 2026Trials0 citationsOpen Access

Fibrinogen Concentrates vs Cryoprecipitate in Liver Transplantation

Fibrinogen concentrates versus cryoprecipitate for intraoperative hypofibrinogenemia in liver transplantation: study protocol for a randomized trial (FIBCRYO-LT trial)

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Authors

YBYu Jeong BangCOChung-Sik OhDLDong Kyu Lee

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Overview

Randomized trial compares fibrinogen concentrate and cryoprecipitate for managing intraoperative hypofibrinogenemia in liver transplantation, suggesting improved outcomes.

Key Points

  • This trial aims to compare the effectiveness of fibrinogen concentrates versus cryoprecipitate for intraoperative hypofibrinogenemia during liver transplantation.
  • Randomized trial designed for liver transplantation patients requiring fibrinogen supplementation.
  • Patients are randomly assigned (1:1) to receive either cryoprecipitate or fibrinogen concentrate.
  • Primary outcome is treatment time (T-time) until completion of intravenous administration.
  • Expected shorter T-time in the fibrinogen concentrate group indicating faster management of hypofibrinogenemia.
  • Potential reduction in perioperative bleeding and transfusion requirements with fibrinogen concentrate.
  • Improved overall perioperative outcomes from faster coagulation management.
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Cite This Study

Bang et al. (2026) studied this question.

synapsesocial.com/papers/6a23bad471a5da9775e767d5https://doi.org/10.1186/s13063-026-09805-1
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