Photophysical and thermodynamic delineation of binding interactions of anticancer alkaloid chelerythrine towards triplex and duplex DNA structures: a comparative approach

Q: What does this research mean for the field?

The anticancer alkaloid chelerythrine exhibits distinct photophysical and thermodynamic binding interactions when interacting with triplex compared to duplex DNA structures. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Rapti Goswami; Himal Das; Lopa Paul; Amar Ghosh; Susmita Chowdhury; Ribhu Banerjee; Suman Das

doi:10.1039/d6cp00161k

January 1, 2026Physical Chemistry Chemical Physics

Photophysical and thermodynamic delineation of binding interactions of anticancer alkaloid chelerythrine towards triplex and duplex DNA structures: a comparative approach

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Key Points

This research aims to explore the binding interactions of the anticancer alkaloid chelerythrine with different DNA structures, specifically triplex and duplex DNA.
Conducted photophysical and thermodynamic analyses to assess binding interactions.
Compared the interaction effects between chelerythrine and duplex versus triplex DNA.
Utilized various experimental techniques to evaluate nucleic acid structure functionalities.
Chelerythrine exhibited distinct binding affinities for triplex DNA compared to duplex DNA.
The binding interactions were characterized by specific photophysical changes.
Thermodynamic parameters indicated favorable binding enthalpy and entropy for triplex DNA.

Implication

Comparative analysis of chelerythrine interactions with triplex and duplex DNA structures highlights its potential in gene therapy.

Abstract

Higher-order nucleic acid structures have garnered attention nowadays in the field of active cancer research owing to their wide range of applications in gene regulation and targeted gene therapy.

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Cite This Study

Goswami et al. (2026) studied this question.

synapsesocial.com/papers/6a23bb4471a5da9775e76d19 https://doi.org/10.1039/d6cp00161k

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Photophysical and thermodynamic delineation of binding interactions of anticancer alkaloid chelerythrine towards triplex and duplex DNA structures: a comparative approach

Key Points

Implication

Abstract

Discussion

Cite This Study

Photophysical and thermodynamic delineation of binding interactions of anticancer alkaloid chelerythrine towards triplex and duplex DNA structures: a comparative approach

Key Points

Implication

Abstract

Discussion

Cite This Study

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