Sickle Cell Disease

Sickle cell disease is a complex syndrome characterized by hemolytic anemia, vaso-occlusion, and infarctions affecting virtually every organ system. Prominent lung findings include pneumonia, acute chest syndrome, and pulmonary fibrosis. Abdominal imaging can display splenic and renal infarcts, sequestration syndrome, papillary necrosis, and hemosiderosis. Musculoskeletal findings frequently include marrow reconversion, extramedullary hematopoiesis, osteonecrosis, and osteomyelitis. Neurologic complications are common and include ischemic stroke, Moyamoya disease, cerebral aneurysm, and intracranial hemorrhage.