Why the study?
It was unknown whether a higher exercise dosage provides the same cardiac autonomic modulation benefits as a lower dosage in patients after CABG.
Does an in-hospital mobilization exercise program performed once or twice daily improve cardiac autonomic modulation in patients post-CABG?
Does an in-hospital mobilization exercise program performed once or twice daily improve cardiac autonomic modulation in patients post-CABG?
In-hospital mobilization exercise, whether performed once or twice daily, improves cardiac autonomic modulation at discharge in post-CABG patients compared to usual care alone.
Twice-daily in-hospital exercise was associated with improved autonomic modulation post-CABG; extends prior evidence but remains hypothesis-generating pending RCTs.
Background: Coronary artery bypass surgery (CABG) implies in impairment of cardiac autonomic modulation (CAM). In-hospital mobilization positively affects CAM; however, it is not known whether higher exercise dosage would provide the same benefits in CAM as lower dosage in patients post-CABG. Aims: To investigate the dose-effect of an exercise inpatient program performed once or twice-daily on cardiac autonomic modulation post-CABG. Design: Prospective trial with a quasiexperimental design. Methods: Thirty patients of both sexes with a diagnosis of coronary heart disease and first-time post-CABG were allocated in a non-random manner into GEX1 (n = 10) and GEX2 (n = 10), composed of patients engaged in one and two daily exercise sessions plus usual care (breathing exercises, education with no systematized mobilization exercise program), respectively; and control group (CG, n = 10), composed of those who only received usual care. Patients underwent a mobilization protocol until discharge, which included a progressive five steps of active-assistive exercises of lower/upper limbs. Heart rate (HR) and R-wave intervals (RRi) were recorded by heart rate monitor at basal condition and discharge time. CAM was assessed by heart rate variability (HRV). Results: At discharge, the higherdose group (GEX2) showed significant higher values of: parasympathetic (RMSSD: 7.91.3 ms vs 4.60.4 ms) and overall CAM indexes (STD RR: 7.51.1 ms vs 4.80.5 ms and TINN (386.4 ms vs 232.8 ms) compared with CG, respectively. In addition, mean HR (GEX2: 88.1 12.3 bpm; GEX1: 79.45.7 bpm, CG: 100.410.1 bpm) and mean RR (GEX2: 694.0101.8 bpm; GEX1: 759.157.0 bpm, CG: 602.859.1 bpm) were different to exercise groups compared to controls regardless dosage. However, there was no significant difference between the exercise groups (GEX1 and GEX2). Conclusions: Regardless dosage, post-CABG patients who engaged in a mobilization-exercise program demonstrated better cardiac autonomic modulation at discharge compared with the control group. The results are encouraging further investigation in the field of in-hospital exercise rehabilitation dosage on cardiac autonomic modulation in a more comprehensive sample to strengthen the findings.
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Mendes et al. (2021) studied this question.
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