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June 6, 2026OxygenOpen Access

The Role of Supplemental Oxygen for Rescuers Performing External Cardiac Compressions: A Double-Blinded Randomized Crossover Trial

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Authors

BMBiswadev MitraJCJackson CatalanoPJP Jennings

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Overview

Randomized trial assesses supplemental oxygen's impact on ECC quality in emergency clinicians, suggesting no significant improvement.

Key Points

  • This research aims to evaluate the effect of supplemental low-flow oxygen on the quality and duration of external chest compressions by emergency clinicians.
  • Double-blinded randomized crossover trial involving emergency medicine doctors, nurses, and paramedics.
  • Participants received either oxygen or air via nasal cannula during chest compressions on a resuscitation manikin.
  • Primary outcome measured was time to inadequate CPR and secondary outcomes included compression rate and depth.
  • No significant differences in time to inadequate CPR or compression rates among the three study arms.
  • A statistically significant difference was found in compression depth between control (51.5 mm) and air (48.0 mm; p=0.015).
  • Overall, supplemental oxygen did not enhance the performance of ECC per international guidelines.

Cite This Study

Mitra et al. (2026) studied this question.

synapsesocial.com/papers/6a23bbeb71a5da9775e7745dhttps://doi.org/10.3390/oxygen6020014
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of partial pressure of oxygen between compression-only CPR and standard CPR in simulated adult cardiac arrest - A manikin-based clinical modelling2025
  2. 2Ambient oxygen enrichment during cardiopulmonary resuscitation: an overestimated risk? - Insights from a manikin study2026
  3. 3Mechanical versus manual chest compressions during ECPR in the catheterization laboratory2026
  4. 4Mechanical versus Manual Chest Compressions for Cardiopulmonary Resuscitation in Emergency Department: A Comparative Study2025
  5. 5Effectiveness of innovative chest compression on the emergency department stretcher by an alternative method: a randomized controlled crossover trial2024 · 1 citations