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June 6, 2026Open Access

Stability Indicating Method Development and Validation of Lacosamide and Its Related Substances in Pharmaceutical Formulation by Rp-HPLC

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Authors

DBDr. Ch. Saibabu*1, K. Bhargavi2, Dr. M. Bhaskar3

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Overview

Randomized trial demonstrates a robust method for analyzing Lacosamide impurities in pharmaceutical formulations, suggesting improved quality control measures.

Key Points

  • The aim is to develop a reliable method for detecting related substances of Lacosamide in pharmaceuticals.
  • Developed a high performance liquid chromatographic method using specific buffers and mobile phases.
  • Validated the method for various parameters including specificity and recovery.
  • Applied the method to commercial pharmaceutical products for impurity analysis.
  • Achieved a recovery rate of 96.92% for Lacosamide at the 100% level.
  • Calibration curves showed linearity with a correlation coefficient of 0.999 within the defined range.
  • No interference was noted with degradation products during stability testing.

Cite This Study

Dr. Ch. Saibabu*1, K. Bhargavi2, Dr. M. Bhaskar3 (2026) studied this question.

synapsesocial.com/papers/6a23bc5171a5da9775e77a2ehttps://doi.org/10.5281/zenodo.20537055
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