Nidanarthakara Vyadhi – Conceptual Understanding With Special Reference to Pmos

Nidānārthakara Vyādhi is a distinctive pathological principle described in the classical texts of Ayurveda, wherein an existing disease itself acts as the causative factor (Nidana) for the development of another disease. This concept illustrates the dynamic, progressive and interrelated nature of disease manifestation explained in Ayurvedic science. It emphasizes the significance of early diagnosis, timely therapeutic intervention and prevention of disease progression through appropriate management of Doṣa, Duṣya, Agni and Srotas. In the contemporary era, lifestyle disorders and endocrine disturbances have shown increasing prevalence among reproductive-aged women. However, polycystic ovaries are detected in 20% to 30% of all women, so this finding is not specific. It affects 6% to 10% of reproductive age women worldwide. It is also associated with obesity, type 2 diabetes, all of which may be indicative of an underlying metabolic disorder. Among these, Polycystic Ovarian Syndrome (PCOS), presently being redefined in broader metabolic perspectives as Polyendocrine Metabolic Ovarian Syndrome (PMOS). If left untreated, PCOS may further progress and predispose individuals to represents a multidimensional disorder involving reproductive, metabolic and psychological. This review aims to explore the concept of Nidānārthakara Vyādhi in classical Ayurvedic literature and assess the role of PMOS as a Nidānārthakara Vyādhi in the development of Secondary disease conditions.