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SUMO-specific proteases/isopeptidases: SENPs and beyond | Synapse

July 30, 2014Genome biology231 citationsOpen Access

SUMO-specific proteases/isopeptidases: SENPs and beyond

ANArnab NayakMedizinische Hochschule Hannover SMStefan MüllerGoethe University Frankfurt

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Resumen

We summarize the evolutionary relationship, structure and subcellular distribution of SUMO proteases (or SUMO isopeptidases). We also discuss their functions and allude to their involvement in human disease.

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Nayak et al. (Wed,) studied this question.

synapsesocial.com/papers/6a23bf8e003b3cd7fea60b8c https://doi.org/https://doi.org/10.1186/s13059-014-0422-2

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Characterization of SENP7, a SUMO-2/3-specific isopeptidase2009 · 110 citations
2Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family2007 · 52 citations
3SUMO protease SENP1 induces isomerization of the scissile peptide bond2006 · 123 citations
4A Basis for SUMO Protease Specificity Provided by Analysis of Human Senp2 and a Senp2-SUMO Complex2004 · 194 citations
5SUMO routes ribosome maturation2011 · 74 citations