Cyclic Nucleotide-Dependent Protein Kinases, Iv. Widespread Occurrence of Adenosine 3′,5′-Monophosphate-Dependent Protein Kinase in Various Tissues and Phyla of the Animal Kingdom

Adenosine 3',5'-monophosphate-dependent protein kinase activity was found in about thirty sources including many mammalian tissues as well as species representative of eight different invertebrate phyla. The data support a unifying theory for the mechanism of action of adenosine 3',5'-monophosphate, namely that its many and diverse effects are mediated through activation of tissue-specific protein kinases.