Key result
Currently available tests for platelet activation, such as mean platelet volume and flow cytometry, lack sufficient predictive value or practicality for routine vascular risk assessment.
Why the study?
Is there a practical, simple, and cost-effective index of platelet activity that predicts the risk of coronary heart disease and vascular events?
Population
Healthy individuals and patients at risk of coronary heart disease and vascular events
Design
Review
Authors
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Available tests should not guide vascular risk assessment; leaves open need for validated, practical platelet biomarkers.
Is there a practical, simple, and cost-effective index of platelet activity that predicts the risk of coronary heart disease and vascular events?
Currently available tests for platelet activation, including MPV and flow cytometry, lack sufficient evidence or practicality to be used routinely for predicting vascular risk in large populations.
Tsiara et al. (2003) conducted a review in Coronary heart disease and vascular events. Platelet activation tests (e.g., MPV, platelet aggregation, soluble P-selectin, flow cytometry) was evaluated on Prediction of the risk of CHD and vascular events. Currently available tests for platelet activation, such as mean platelet volume and flow cytometry, lack sufficient predictive value or practicality for routine vascular risk assessment.
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