Key result
Raised plasma levels of von Willebrand factor independently predicted vascular events in aspirin-treated patients with atrial fibrillation (RR 1.2; 95% CI 1.0-1.4; P=0.02 per 20 IU/dL increase).
Why the study?
Do raised plasma levels of von Willebrand factor and soluble P-selectin predict stroke and vascular events in patients with nonvalvular atrial fibrillation receiving aspirin?
Cohort (n=994)
Do raised plasma levels of von Willebrand factor and soluble P-selectin predict stroke and vascular events in patients with nonvalvular atrial fibrillation receiving aspirin?
Relative Risk: 1.2 (95% CI 1–1.4)
p-value: p=0.02
Elevated plasma von Willebrand factor, an index of endothelial damage, independently predicts vascular events in aspirin-treated patients with nonvalvular atrial fibrillation.
No takes yet. Share an insight, caveat, or question.
Elevated vWF may refine vascular risk assessment in aspirin-treated AF; leaves open added value over clinical scores and prospective validation.
Conway et al. (2003) conducted a cohort in Nonvalvular Atrial Fibrillation (n=994). Plasma von Willebrand factor (vWf) and soluble P-selectin (sP-sel) was evaluated on Vascular events (RR 1.2, 95% CI 1.0-1.4, p=0.02). Raised plasma levels of von Willebrand factor independently predicted vascular events in aspirin-treated patients with atrial fibrillation (RR 1.2; 95% CI 1.0-1.4; P=0.02 per 20 IU/dL increase).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: