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The 1,2,3-triazoles have gained significant attention in the field of chemosensors due to their distinctive features, such as the ability to form stable complexes with a variety of metal ions and also their functionalization potential. The modified 1,2,3-triazole analogs may further enhance their selectivity and sensitivity. When coupled with fluorophores or signaling groups, 1,2,3-triazole-based sensors exhibit notable changes in fluorescence, absorbance, or electrochemical signals upon interaction with target analytes that eventually make them highly sensitive tools for environmental, industrial, and biomedical applications. This tutorial review highlights the growing aspects of "click-to-sensing" with recent developments on click-inspired 1,2,3-triazole-based chemosensors and their notable applications.
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Rajkhowa et al. (2025) studied this question.
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