Why the study?
Does sustained upright posture alter vasomotor sympathetic neural control and muscle sympathetic nerve activity compared to the supine position in healthy individuals?
Population
13 healthy individuals
Comparison
45 min 60 deg upright tilt vs Supine position
Design
Other
Follow-up
45 minutes
Key result
Upright posture increased sympathetic baroreflex sensitivity compared to supine (-718 vs -292 units beat-1 mmHg-1; P<0.01), which was maintained without significant change during 45 minutes of tilt.
Authors
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No immediate clinical implications for orthostatic management; leaves open baroreflex dynamics in patients with autonomic or cardiovascular disease.
Does sustained upright posture alter vasomotor sympathetic neural control and muscle sympathetic nerve activity compared to the supine position in healthy individuals?
Absolute Event Rate: -718% vs -292%
p-value: p=<0.01
Vasoconstriction initiated by sympathetic adrenergic nerves is maintained by ongoing sympathetic activation during sustained orthostasis without obvious changes in vasomotor sympathetic neural control.
Fu et al. (2006) studied Healthy (n=13). 60 degree upright tilt vs. Supine posture was evaluated on Sympathetic baroreflex sensitivity (p=<0.01). Upright posture increased sympathetic baroreflex sensitivity compared to supine (-718 vs -292 units beat-1 mmHg-1; P<0.01), which was maintained without significant change during 45 minutes of tilt.