Key result
MALAT1 emerges as a potential MI biomarker and therapeutic target by regulating angiogenesis and inflammation.
Why the study?
Long-term treatment for myocardial infarction remains difficult, prompting evaluation of the role of the lncRNA MALAT1 in MI development and management.
This comprehensive review highlights the significant role of the long non-coding RNA MALAT1 in myocardial infarction, suggesting its potential as a diagnostic biomarker and therapeutic target.
Hypothesis-generating for MALAT1 as MI biomarker and target; prospective trials needed before clinical consideration.
Myocardial infarction (MI) stands at top global causes of death in developed countries, owing mostly to atherosclerotic plaque growth and endothelial injury-induced reduction in coronary blood flow. While early reperfusion techniques have improved outcomes, long-term treatment continues to be difficult. The function of lncRNAs extends to regulating gene expression in various conditions, both physiological and pathological, such as cardiovascular diseases. The objective of this research is to extensively evaluate the significance of the lncRNA called Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) in the development and management of MI. According to research, MALAT1 is implicated in processes such as autophagy, apoptosis, cell proliferation, and inflammation in the cardiovascular system. This investigation examines recent research examining the effects of MALAT1 on heart function and its potential as a mean of diagnosis and treatment for post- MI complications and ischemic reperfusion injury.
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Eshraghi et al. (2024) conducted a review in Myocardial infarction. MALAT1 was evaluated. MALAT1 plays a significant role in myocardial infarction by regulating angiogenesis, apoptosis, cell proliferation, and inflammation, highlighting its potential as a diagnostic biomarker and therapeutic target.
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