The Production of Gamma-Globulin in the Central Nervous System

Murray, and Knaub, 1950) criteria identical with the serum proteins. Apart, however, from being present in considerably lower total concentration the various components do not occur in the same proportions in the cerebrospinal fluid and in the serum. Albumin is preponderant in the cerebro-spinal fluid and oc- and P-globulins are present in amounts which may in normal subjects be too low to be detected. Alterations are found both in the total protein concentration of the cerebrospinal fluid and in the relative concentrations of the com-ponents in disease affecting the central nervous system. Bing and Neel (1942) have reviewed the earlier studies on albumin/globulin ratios obtained by salting-out techniques. These indicated a relative