Identifies the molecular weight of mouse kidney preprorenin as 50,000, confirming it is larger than active renin.
No clinical impact; extends mouse renin precursor characterization but leaves open human translation.
The biosynthetic precursor of renin (preprorenin) from mouse kidney is a single chain polypeptide with a molecular weight of 50 000. 2. This is the same value as previously found for mouse submaxillary gland pre-prorenin. 3. Mouse kidney pre-prorenin (mol. wt. 50 000) is larger than the enzymatically active renin (mol. wt. 40 000).
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Poulsen et al. (1980) studied this question.