Central and peripheral hemodynamic effects of angiotensin inhibition in patients with refractory congestive heart failure.
Why the study?
Does teprotide improve central and peripheral hemodynamics in patients with severe, refractory congestive heart failure?
Population
10 patients with severe, refractory congestive heart failure
Design
Case_series
Follow-up
Acute (simultaneous hemodynamic determination)
Authors
Discussion
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Member takes
Implication
May support afterload reduction in refractory HF; hypothesis-generating, requiring controlled trials before practice change.
Structured PICO
Does teprotide improve central and peripheral hemodynamics in patients with severe, refractory congestive heart failure?
P
Population
10 patients with severe, refractory congestive heart failure
I
Intervention
Teprotide (SQ20881)
O
Outcome
Central and peripheral hemodynamic responses (including mean arterial pressure, systemic vascular resistance, mean pulmonary capillary wedge pressure, and cardiac index)surrogate
Teprotide acutely reduces ventricular afterload and improves cardiac function in patients with severe, refractory congestive heart failure, demonstrating the role of the renin-angiotensin system in regional vasoconstriction.
Cite This Study
Faxon et al. (1980) studied this question.