Key result
Repolarization dispersion and early afterdepolarizations explain most TdP features despite some mechanistic gaps.
Why the study?
Recent studies suggested torsade de pointes may be precipitated by early afterdepolarizations, offering an alternative to the hypothesis attributing it to dispersion of repolarization.
This review highlights that while both dispersion of repolarization and early afterdepolarizations can explain most clinical features of torsade de pointes, the afterdepolarization hypothesis faces challenges in certain cases.
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Both mechanisms explain most torsade de pointes; leaves open targeted experiments to resolve afterdepolarization inconsistencies.
Borys Surawicz (1989) conducted a review in Torsade de pointes. Early afterdepolarizations vs. Dispersion of repolarization was evaluated. Dispersion of repolarization and early afterdepolarizations can explain most clinical features of torsade de pointes, though the afterdepolarization hypothesis faces difficulties in some cases.
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