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The authors report significant worsening of a pre-existing neuropathy in six patients who received "non-toxic" dosages of known neurotoxic agents. Before treatment, baseline total neuropathy score (TNS) averaged 9.5 (range 0 to 19). After chemotherapy (Taxol 125 to 175 mg/m(2) x 4; vincristine 2 to 5 mg; cisplatin 40 mg/m(2) x 8; and thalidomide 60 g), the TNS averaged 22 (range 13 to 29). The authors conclude that functionally disabling toxic neuropathy can occur in patients with pre-existing neuropathy at standard doses.
Chaudhry et al. (Tue,) studied this question.
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