In this communication, we report the synthesis of the three generations of Fréchet-type poly(aryl ether) dendrimers with a diselenide core that demonstrate generation-dependent glutathione peroxidase (GPx) activity with initial reduction rates as high as 2431.20 muM min-1 for the third-generation product, around 1400 times faster than Ebselen. It represents a successful example of using a dendrimer as a model for a GPx mimic.
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Zhang et al. (2004) studied this question.
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