Answers are grounded in this paper and cite their sources.
Adenosine 5'-O-(1-thiotriphosphate), Sp-diastereomer, is cyclized by adenylate cyclase from bovine brain to adenosine 3',5'-cyclic phosphorothioate, Rp diastereomer, establishing inversion of configuration for this reaction. This result can most easily be explained by a direct nucleophilic attack of the 3'-OH group on alpha-phosphorus without involving a covalent enzyme intermediate.
No takes yet. Share an insight, caveat, or question.
Eckstein et al. (1981) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: