Key result
Single-cell and proteomic profiling of human calcific aortic valves identified a disease-driver population of interstitial cells and potential therapeutic targets, including MAOA and CTHRC1.
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Single-cell and proteomic profiling of human calcific aortic valves identified a disease-driver population of interstitial cells and potential therapeutic targets including MAOA and CTHRC1.
and discover potential key regulators of human CAVD. These DDP-VICs demonstrate multi-lineage differentiation and osteogenic properties. Temporal proteomic profiling of DDP-VICs identifies potential targets for therapy, including MAOA and CTHRC1. In vitro loss-of-function experiments confirm our targets. Such a stepwise strategy may be advantageous for therapeutic target discovery in other disease contexts.
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Decano et al. (2022) studied Calcific aortic valve disease (CAVD). Single-cell and proteomic profiling was evaluated on Identification of disease-driver population and therapeutic targets. Single-cell and proteomic profiling of human calcific aortic valves identified a disease-driver population of interstitial cells and potential therapeutic targets, including MAOA and CTHRC1.
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