March 23, 2004AJP Regulatory Integrative and Comparative Physiology

α-Tropomyosin mutations Asp175Asn and Glu180Gly affect cardiac function in transgenic rats in different ways

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Population

Transgenic rats overexpressing alpha-tropomyosin with disease-causing mutations Asp(175)Asn or Glu(180)Gly

Design

Preclinical

Authors

DWDirk WernickeImmanuel Krankenhaus CTCorinna ThielBioSystem (Germany)CDCorina M Duja-Isac

Discussion

Member takes

Implication

Animal model data should not change HCM practice; leaves open mutation-specific Ca2+ mechanisms pending human validation.

Structured PICO

Population

Transgenic rats overexpressing alpha-tropomyosin with disease-causing mutations Asp(175)Asn or Glu(180)Gly

Intervention

Overexpression of alpha-tropomyosin with Asp(175)Asn or Glu(180)Gly mutations

Outcome

Phenotypic changes at molecular, morphological, and physiological levels (including Ca2+ sensitivity, spontaneous Ca2+ waves, and myocardial contraction/relaxation)surrogate

The Asp(175)Asn mutation in alpha-tropomyosin alters Ca2+ handling to compensate for reduced Ca2+ sensitivity, providing mechanistic insight into the pathogenesis of familial hypertrophic cardiomyopathy.

Cite This Study

Wernicke et al. (2004) studied this question.

synapsesocial.com/papers/6a240be99e1c90a91c099b22 https://doi.org/10.1152/ajpregu.00620.2003

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α-Tropomyosin mutations Asp175Asn and Glu180Gly affect cardiac function in transgenic rats in different ways

Discussion

Member takes

Implication

Structured PICO

Cite This Study

α-Tropomyosin mutations Asp175Asn and Glu180Gly affect cardiac function in transgenic rats in different ways

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider