Key result
Titrating lipid-lowering therapy during cardiac rehab is linked to a ~13% reduction in LDL-C.
Why the study?
Cardiac rehabilitation improves quality of life and prognosis in CHD, but the effects of lipid-lowering therapy during and after cardiac rehabilitation required evaluation.
Does optimization of lipid-lowering therapy during cardiac rehabilitation improve long-term adherence and reduce LDL-C levels in patients with coronary heart disease?
Observational (n=1,100)
Yes
Does optimization of lipid-lowering therapy during cardiac rehabilitation improve long-term adherence and reduce LDL-C levels in patients with coronary heart disease?
Effect estimate: relative reduction of 13.2%
Absolute Event Rate: 1.97% vs 2.27%
p-value: p=<0.001
Cardiac rehabilitation effectively optimizes lipid-lowering therapy, leading to sustained reductions in LDL-C and high long-term statin adherence at 12 months.
Lipid-lowering optimization during cardiac rehabilitation was associated with lower LDL-C; leaves open effects on long-term adherence or outcomes.
Background Cardiac rehabilitation (CR) improves quality of life and prognosis in patients with coronary heart disease (CHD). The aim of the study was to evaluate effects of lipid-lowering therapy (LLT) in patients with CHD during and after CR. Methods Data from prospective, multicenter registry including 1,100 patients with CHD undergoing CR in 6 German cardiac rehabilitation centers between 2016 and 2018 were analyzed. Results The rate of statin-treated patients increased from 1,048 (96.3%) on admission to 1,062 (98.4%) at discharge ( p < 0.001), falling to 644 (96.3%) and 609 (94.1%) at 3 and 12 months, respectively. Combination treatment with ezetimibe was effective in 8.9% of patients at admission and 28.5% at discharge ( p < 0.001), and 23.5% and 25.8% after 3 month and 12 months, respectively. Titration of LLT during CR resulted in median LDL-C-values of 2.27 mmol/L at admission, 1.97 mmol/L at discharge ( p < 0.001), 1.94 mmol/L after 3 months, and 1.94 mmol/L after 12 months, respectively. Conclusions During CR, LLT was effectively instituted and titrated, resulting in a high rate of statin-treated patients and a significant reduction in LDL-C. From this study, we hypothesize that CR is efficacious for adherence to LLT.
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Noack et al. (2025) conducted an observational in Coronary heart disease (n=1,100). Cardiac rehabilitation and lipid-lowering therapy optimization vs. Admission (baseline) was evaluated on Median LDL-C levels at discharge compared to admission (relative reduction of 13.2%, p=<0.001). During cardiac rehabilitation, lipid-lowering therapy was effectively titrated, resulting in a significant reduction in median LDL-C from 2.27 mmol/L at admission to 1.97 mmol/L at discharge.
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