Key result
Intravenous lidocaine significantly increased QRS amplitude in leads V2 and V3 by a mean of 0.1 mV (p<0.005) and mildly prolonged R-to-S duration by 0.8 ms (p<0.02).
Why the study?
Does intravenous lidocaine alter total QRS amplitude and R-to-S duration in patients hospitalized in the coronary care unit?
Observational (n=11)
Does intravenous lidocaine alter total QRS amplitude and R-to-S duration in patients hospitalized in the coronary care unit?
Intravenous lidocaine administration causes a significant increase in QRS amplitude and mild prolongation of R-to-S duration, which could potentially serve as a feedback parameter for closed-loop administration systems.
Answers are grounded in this paper and cite their sources.
QRS changes with lidocaine warrant no practice change; hypothesis-generating for closed-loop feedback systems pending validation.
The influence of an intravenous push of lidocaine 1 mg/kg followed by 2 mg/min infusion on total QRS amplitude and R-to-S duration in leads V2-V4 of the electrocardiogram was studied in 11 patients who were hospitalized in the coronary care unit. A computerized system sampled the amplitude and timing of peak R and S waves of 1100 QRS complexes of leads V2-V4, starting two minutes before the first push of lidocaine. Curves of amplitude and R-to-S duration versus time were obtained in all patients. QRS amplitude in V2 and V3 increased significantly in 10 of 11 patients (p < 0.005). The mean voltage increase for all patients was 0.1 +/- 0.07 millivolt. The authors also observed a mild prolongation of R-to-S duration (0.8 +/- 1.0 millisecond p < 0.02). This new finding, obtained by a simple computerized system, may possibly have potential future practical clinical application as a feedback parameter for closed-loop control systems for the administration of lidocaine.
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Leor et al. (1993) conducted an observational in Hospitalized in the coronary care unit (n=11). Lidocaine vs. Baseline was evaluated on Total QRS amplitude and R-to-S duration in leads V2-V4 (Mean increase 0.1 mV, p=<0.005). Intravenous lidocaine significantly increased QRS amplitude in leads V2 and V3 by a mean of 0.1 mV (p<0.005) and mildly prolonged R-to-S duration by 0.8 ms (p<0.02).
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