Key result
Endothelial-derived microparticles >355/µl independently predicted early recurrence of atrial fibrillation following pulmonary vein isolation (HR 4.92).
Why the study?
Does pulmonary vein isolation increase procoagulant activity via phosphatidylserine exposure, and do these markers predict early recurrence of atrial fibrillation?
Cohort (n=96)
No
Does pulmonary vein isolation increase procoagulant activity via phosphatidylserine exposure, and do these markers predict early recurrence of atrial fibrillation?
Hazard Ratio: 4.92 (95% CI 2.25–10.74)
p-value: p=0.0001
Pulmonary vein isolation increases procoagulant activity via phosphatidylserine exposure on blood cells and microparticles, and elevated endothelial-derived microparticles and hs-CRP independently predict early recurrence of atrial fibrillation.
Elevated EMPs may prompt closer post-PVI monitoring; hypothesis-generating for microparticle-targeted strategies in AF ablation.
The present study aimed to evaluate the procoagulant effects of phosphatidylserine (PS) exposure on blood cells and microparticles (MPs), and examine its role in predicting early recurrence atrial fibrillation (ERAF) in patients with atrial fibrillation (AF) treated with pulmonary vein isolation (PVI). Blood samples were obtained from 40 healthy controls and 56 patients with AF at baseline (prior to PVI), and 0, 1 h, 1 day, 3 days and 7 days following PVI. The exposure of PS (PS+) to blood cells (platelets, erythrocytes and leukocytes) and MPs was detected using flow cytometry. The procoagulant activity was evaluated by coagulation time, and the formation of factor Xa (FXa) and thrombin. In addition, independent factors associated with PS+ blood cells and MPs, and significant predictors of ERAF following PVI were investigated by statistical analyses. The numbers of PS+ blood cells and MPs were significantly increased by PVI (P<0.01). A significant decrease in coagulation time, and increases in FXa and thrombin were exhibited in the PS+ blood cells and MPs from patients with AF treated with PVI, whereas these alterations were inhibited by either lactadherin or anti‑tissue factor (P<0.01). The maximum power of the PVI was significantly associated with platelet‑derived MPs, and high‑sensitivity C‑reactive protein (hs‑CRP) was closely associated with leukocyte‑derived MPs and endothelial‑derived MPs (EMPs) (P<0.01). In addition, hs‑CRP and EMPs >355/µl were identified as independent predictors of ERAF (P<0.05). The increased numbers of PS+ platelets, erythrocytes, leukocytes and MPs contributed to the procoagulant state of AF, and hs‑CRP and EMPs were able to predict ERAF following PVI.
No takes yet. Share an insight, caveat, or question.
Meng et al. (2017) conducted a cohort in Atrial fibrillation (n=96). Endothelial-derived microparticles (EMPs) >355/µl vs. EMPs ≤355/µl was evaluated on Early recurrence of atrial fibrillation (ERAF) (HR 4.92, 95% CI 2.25-10.74, p=0.0001). Endothelial-derived microparticles >355/µl independently predicted early recurrence of atrial fibrillation following pulmonary vein isolation (HR 4.92).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: