Key result
Marathon running significantly increased plasma levels of miR-1, miR-133a, and miR-30a (p<0.001), which correlated with left atrial diameter in elite runners, suggesting their potential as biomarkers for atrial remodeling.
Why the study?
Does marathon running and endurance training alter circulating microRNA levels associated with atrial remodeling in healthy male runners?
Observational (n=30)
No
Does marathon running and endurance training alter circulating microRNA levels associated with atrial remodeling in healthy male runners?
p-value: p=<0.001
Circulating microRNAs (miR-1, miR-133a) increase significantly after marathon running in elite athletes and correlate with left atrial diameter, suggesting their potential utility as biomarkers for exercise-induced atrial remodeling.
May support miRNA monitoring for atrial remodeling in elite athletes; hypothesis-generating and should not yet change practice.
INTRODUCTION: Physical activity is beneficial for individual health, but endurance sport is associated with the development of arrhythmias like atrial fibrillation. The underlying mechanisms leading to this increased risk are still not fully understood. MicroRNAs are important mediators of proarrhythmogenic remodeling and have potential value as biomarkers in cardiovascular diseases. Therefore, the objective of our study was to determine the value of circulating microRNAs as potential biomarkers for atrial remodeling in marathon runners (miRathon study). METHODS: 30 marathon runners were recruited into our study and were divided into two age-matched groups depending on the training status: elite (ER, ≥55 km/week, n = 15) and non-elite runners (NER, ≤40 km/week, n = 15). All runners participated in a 10 week training program before the marathon. MiRNA plasma levels were measured at 4 time points: at baseline (V1), after a 10 week training period (V2), immediately after the marathon (V3) and 24h later (V4). Additionally, we obtained clinical data including serum chemistry and echocardiography at each time point. RESULTS: MiRNA plasma levels were similar in both groups over time with more pronounced changes in ER. After the marathon miR-30a plasma levels increased significantly in both groups. MiR-1 and miR-133a plasma levels also increased but showed significant changes in ER only. 24h after the marathon plasma levels returned to baseline. MiR-26a decreased significantly after the marathon in elite runners only and miR-29b showed a non-significant decrease over time in both groups. In ER miRNA plasma levels showed a significant correlation with LA diameter, in NER miRNA plasma levels did not correlate with echocardiographic parameters. CONCLUSION: MiRNAs were differentially expressed in the plasma of marathon runners with more pronounced changes in ER. Plasma levels in ER correlate with left atrial diameter suggesting that circulating miRNAs could potentially serve as biomarkers of atrial remodeling in athletes.
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Clauß et al. (2016) conducted an observational in Healthy marathon runners (n=30). Marathon running vs. Baseline/Pre-marathon was evaluated on Change in miR-1, miR-133a, and miR-30a plasma levels immediately after marathon (p=<0.001). Marathon running significantly increased plasma levels of miR-1, miR-133a, and miR-30a (p<0.001), which correlated with left atrial diameter in elite runners, suggesting their potential as biomarkers for atrial remodeling.
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