Key result
Low-voltage zone targeting during AF ablation is associated with better outcomes than empirical ablation.
Why the study?
Many ablation approaches targeting extrapulmonary substrate beyond pulmonary vein isolation in AF are empirical, while tailoring ablation through atrial voltage mapping may improve clinical outcomes.
Does voltage-guided ablation targeting the arrhythmogenic substrate improve outcomes in patients with atrial fibrillation?
Does voltage-guided ablation targeting the arrhythmogenic substrate improve outcomes in patients with atrial fibrillation?
Individualized ablation strategies guided by atrial voltage mapping to target fibrotic substrates may offer superior long-term success rates over standard empirical pulmonary vein isolation.
May support voltage-guided AF ablation; leaves open confirmation of benefit in randomized trials.
The interplay between triggers, arrhythmogenic substrate and modulators determines the pathophysiological and cli-Although mainly based on pulmonary vein isolation empirical ablation approaches targeting extrapulmonary substrate have also been introduced. These include creation of linear lesions, extensive ablation of LA posterior wall, targeting fractionated electrograms, rotors maintaining AF, etc. However, many of these approaches are just empirical and do introduced to explain the occurrence and clinical course of many conditions including AF. Atrial voltage mapping is incablation of AF seems to be associated with better clinical outcomes. This review focuses on the association between atrial substrate. It also summarises the available data from clinical trials examining the role of voltage-driven ablation on procedural outcome on AF patients.
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Vassil Traykov (2020) conducted a review in Atrial fibrillation. Voltage-guided atrial fibrillation ablation vs. Empirical ablation (standard pulmonary vein isolation) was evaluated. Targeting low voltage zones during catheter ablation of atrial fibrillation seems to be associated with better clinical outcomes compared to standard empirical ablation approaches.
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