Why the study?
Does intracellular free-calcium concentration in platelets correlate with blood pressure in hypertensive and normotensive subjects, and does it decrease with antihypertensive therapy?
Population
92 subjects, including 9 patients with borderline hypertension, 45 patients with established essential…
Comparison
Antihypertensive treatment with calcium-entry… vs Normotensive subjects for baseline comparison…
Design
Cohort
Authors
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Platelet calcium tracks BP changes; supports biomarker research but leaves open causal role and clinical utility.
Does intracellular free-calcium concentration in platelets correlate with blood pressure in hypertensive and normotensive subjects, and does it decrease with antihypertensive therapy?
Intracellular free-calcium concentration in platelets strongly correlates with blood pressure and decreases with antihypertensive therapy, suggesting shared regulatory mechanisms.
Erné et al. (1984) studied this question.
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