What does this research mean for the field?

The altered epidemiology of RSV during the COVID-19 pandemic is likely driven by a combination of decreased population immunity due to lack of viral circulation, SARS-CoV-2-induced immune dysregulation, viral interactions, and changes in healthcare-seeking behaviors. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 1, 2023EClinicalMedicine184 citationsOpen Access

Why has the epidemiology of RSV changed during the COVID-19 pandemic?

BABahaa Abu-RayaDalhousie University MPMarina Viñeta ParamoUniversity of British Columbia FRFrederic ReicherzUniversity of British Columbia

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Abstract

The coronavirus disease 2019 (COVID-19) pandemic has drastically perturbed the epidemiology of Respiratory Syncytial Virus (RSV) respiratory tract infections in children. The reasons for this are not clear. In this article, we review the current literature and critically discuss the different theories to explain why the epidemiology of RSV has changed during the COVID-19 pandemic. Proposed mechanisms include decreased viral immunity in vulnerable age groups caused by the prolonged lack of RSV circulation early in the pandemic, potential Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2)-induced immune dysregulation, viral interactions between SARS-CoV-2 and RSV, and modifications in health-seeking behaviors as well as heath systems factors. Research in viral genomics and phylogeny, and more robust immunology research is needed to guide RSV prevention and health care resource planning.

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