New components of contemporary arrhythmology – the basics of pathogenesis and their clinical justification

Q: What is the clinical evidence from this study?

Study design: Case Report. Population: Ischemic heart disease with arrhythmias and conduction disorders (n=4). Intervention: Ranolazine vs. Standard therapy (baseline). Primary outcome: Reduction in rhythm and conduction disturbances (supraventricular tachycardia, ventricular extrasystoles, AV block, LBBB).

Svitlana Andrievskaya; V. K. Krotenko; V. A. Kolesnik

doi:10.37987/1997-9894.2019.8(234).187158

October 2, 2019Medicine of UkraineOpen Access

New components of contemporary arrhythmology – the basics of pathogenesis and their clinical justification

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Why the study?

Does ranolazine reduce rhythm and conduction disturbances in patients with ischemic heart disease?

Study Design

Type

Case Report (n=4)

Structured PICO

Does ranolazine reduce rhythm and conduction disturbances in patients with ischemic heart disease?

P

Population

Four patients with ischemic heart disease and rhythm or conduction disturbances treated with ranolazine in addition to standard therapy.

I

Intervention

Ranolazine 500 mg oral twice a day, followed by an increase to 1000 mg twice a day, added to standard treatment complex.

C

Comparator

Standard therapy alone (pre-treatment baseline in a case series format).

O

Outcome

Reduction in the number of rhythm and conduction disturbances and restoration of intraventricular and atrioventricular conductivity assessed by ECG and Holter monitoring.surrogate

Limitations

Small sample size (case series)
Lack of a control group
Observational nature of the cases

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Implication

Ranolazine may offer antiarrhythmic benefits and improve conduction disturbances when added to standard therapy in patients with ischemic heart disease.

Abstract

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Cite This Study

Andrievskaya et al. (2019) conducted a case report in Ischemic heart disease with arrhythmias and conduction disorders (n=4). Ranolazine vs. Standard therapy (baseline) was evaluated on Reduction in rhythm and conduction disturbances (supraventricular tachycardia, ventricular extrasystoles, AV block, LBBB).

synapsesocial.com/papers/6a24de6dd225cdb21ef512c6 https://doi.org/10.37987/1997-9894.2019.8(234).187158

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New components of contemporary arrhythmology – the basics of pathogenesis and their clinical justification

Study Design

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

New components of contemporary arrhythmology – the basics of pathogenesis and their clinical justification

Study Design

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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