Why the study?
Does zinc sulfate inhibit herpes simplex virus replication in infected BSC-1 cells?
Does zinc sulfate inhibit herpes simplex virus replication in infected BSC-1 cells?
Zinc sulfate irreversibly inhibits herpes simplex virus replication in BSC-1 cells in a dose-dependent manner.
In vitro zinc inhibition of HSV is hypothesis-generating; clinical relevance requires prospective validation.
Zinc sulfate added to the medium of herpes simplex virus-infected BSC-1 cells, at a concentration of 0.1 mM, inhibited the synthesis of infectious virus progeny by 95 to 96%. A concentration of 0.2 mM zinc sulfate inhibited herpes simplex virus synthesis by 99.8% as determined by centrifugation in sucrose gradients and by plaque assay on BSC-1 monolayers. The inhibition of herpes simplex virus replication in BSC-1 cells was found to be irreversible.
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Gordon et al. (1975) studied this question.
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