NRF2-mediated inhibition of alveolar macrophage MHC II expression during Mycobacterium tuberculosis infection

Q: What does this research mean for the field?

During Mycobacterium tuberculosis infection, NRF2 mediates the inhibition of MHC II expression in alveolar macrophages, which is linked to T cell activation and host immunity. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Linh K. Pham; Maritza M. Cervantes; Pamelia N. Lim; Divya Dubey; Ankita Tufts; M. Clare Mitchell; Tomoyo Shinkawa; Samuel M. Behar; Alissa C. Rothchild

doi:10.1016/j.celrep.2026.117397

June 1, 2026Cell ReportsOpen Access

NRF2-mediated inhibition of alveolar macrophage MHC II expression during Mycobacterium tuberculosis infection

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Key Points

The research aims to explore how Nrf2 affects MHC II expression in alveolar macrophages during Mycobacterium tuberculosis infection.
Examined the role of Nrf2 in alveolar macrophages during Mycobacterium tuberculosis infection
Analyzed T cell activation and host immune responses
Investigated MHC II expression levels
Nrf2 signaling significantly inhibits MHC II expression on alveolar macrophages
This inhibition alters T cell activation and impacts host immunity during infection
Findings suggest a potential therapeutic target for enhancing immune responses to tuberculosis

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Implication

Investigates MHC II expression in alveolar macrophages during Mtb infection, highlighting immune mechanisms.

Abstract

T cell activation and host immunity during Mtb infection.

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Cite This Study

Pham et al. (2026) studied this question.

synapsesocial.com/papers/6a25098a7def13d035e19f70 https://doi.org/10.1016/j.celrep.2026.117397

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NRF2-mediated inhibition of alveolar macrophage MHC II expression during Mycobacterium tuberculosis infection

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

NRF2-mediated inhibition of alveolar macrophage MHC II expression during Mycobacterium tuberculosis infection

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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