Key result
Erratum clarifies that heightened FRET efficiency indicates lower focal adhesion tension.
This erratum corrects the interpretation of FRET efficiency in relation to focal adhesion tension in a basic science study on dilated cardiomyopathy.
Erratum reverses FRET-tension link in focal adhesions; leaves open revised fibroblast mechanics in dilated cardiomyopathy models.
In the Research Article “Preventing hypocontractility-induced fibroblast expansion alleviates dilated cardiomyopathy” by R. Bretherton et al. (11 September 2025, 10.1126/science.adv9157), the authors have corrected errors that arose from misinterpreting FRET efficiency. Heightened FRET efficiency exhibits lower focal adhesion tension, not higher focal adhesion tension as the original text indicated. The text and Fig. 3 legend have been revised accordingly. In addition, more detailed methods and two corresponding supporting references (references 89 and 90) have been added for vinculin FRET-tension sensor experiments (materials and methods section “Vinculin FRET measurements and analysis”).
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A 2026 study studied Dilated cardiomyopathy. The erratum corrects the interpretation of FRET efficiency, clarifying that heightened FRET efficiency exhibits lower focal adhesion tension rather than higher tension.
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