Intravenous immunoglobulin enhances intestinal stem cell regeneration to mitigate radiation-induced enteritis via promoting β-catenin nuclear translocation

Q: What does this research mean for the field?

Intravenous immunoglobulin (IVIg) mitigates radiation-induced enteritis by enhancing intestinal stem cell regeneration through the promotion of β-catenin nuclear translocation. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Jia He; Tiancheng Chu; Ping Fu; Peng Jiang (16544); Li Ma; Fengjuan Liu; Xi Du; Zhenni Xu; Jun Xu; Lu Cheng; Changqing Li; Dengqun Liu; Zongkui Wang

doi:10.1016/j.stemcr.2026.102934

June 1, 2026Stem Cell ReportsOpen Access

Intravenous immunoglobulin enhances intestinal stem cell regeneration to mitigate radiation-induced enteritis via promoting β-catenin nuclear translocation

View Full Paper

Ask AI

Bookmark

Share

Key Points

To investigate the effects of intravenous immunoglobulin (IVIg) on intestinal stem cell (ISC) regeneration following radiation-induced enteritis (RIE).
Examined the impact of IVIg on ISC survival and regeneration post-radiation exposure.
Evaluated the role of β-catenin nuclear translocation in mediating IVIg's effects.
Utilized β-catenin inhibitor MSAB to assess IVIg's radioprotective mechanisms.
IVIg significantly enhanced ISC regeneration compared to control, improving cell survival rates.
Inhibition of β-catenin with MSAB reduced the protective effects of IVIg, confirming its role in regeneration.
IVIg promoted β-catenin nuclear translocation, a critical pathway for mitigating RIE.

Implication

Demonstrates improved intestinal stem cell regeneration in radiation-induced enteritis, suggesting a new therapeutic approach.

Abstract

ISCs and their daughter cell survival. Mechanistically, IVIg promoted β-catenin nuclear translocation, and the β-catenin inhibitor MSAB diminished IVIg's radioprotective effects. Collectively, IVIg combats RIE by enhancing ISC regeneration via β-catenin nuclear translocation, highlighting its potential as an RIE therapeutic candidate.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

He et al. (2026) studied this question.

synapsesocial.com/papers/6a250a717def13d035e1a989 https://doi.org/10.1016/j.stemcr.2026.102934

View Full Paper

Ask AI

Bookmark

Share

Intravenous immunoglobulin enhances intestinal stem cell regeneration to mitigate radiation-induced enteritis via promoting β-catenin nuclear translocation

Key Points

Implication

Abstract

Discussion

Cite This Study

Intravenous immunoglobulin enhances intestinal stem cell regeneration to mitigate radiation-induced enteritis via promoting β-catenin nuclear translocation

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading