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June 7, 2026Current Research in ToxicologyOpen Access

Elucidating the toxicity of the plasticizer DPhP: Evidence of neurotoxicity and developmental impairment from in vitro to in vivo models

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Authors

LZLipeng ZhuXZXie ZhipengXZXinyang Zhang

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Overview

Experimental models reveal that DPhP exposure disrupts cell growth and neural function, suggesting significant health risks.

Key Points

  • To investigate the toxicity profile of diphenyl phthalate (DPhP) across various biological models and its underlying mechanisms.
  • Utilized human umbilical vein endothelial cell (HUVEC) and Caenorhabditis elegans models for toxicity assessment.
  • Analyzed cell cycle alterations, neurodevelopmental gene expression, and behavioral changes in response to DPhP exposure.
  • Conducted molecular analysis of key signaling pathways associated with DPhP toxicity.
  • DPhP exposure significantly reduced cell viability and proliferation, with associated alterations in cell cycle phases.
  • In C. elegans, DPhP impaired growth and locomotor behavior, with deficits in chemotaxis and learning observed.
  • DPhP disrupted dopaminergic pathways, leading to reduced dopamine levels and loss of dopaminergic neurons.

Cite This Study

Zhu et al. (2026) studied this question.

synapsesocial.com/papers/6a250a717def13d035e1a9echttps://doi.org/10.1016/j.crtox.2026.100304
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