2904-LB: Randomized Controlled Trial (Comparing Use of Real-Time Continuous Glucose Monitoring (rt-CGM) to Fingerstick Testing following Hospitalization for Diabetic Foot Ulcer (DFU)

Introduction and Objective: We conducted a pragmatic RCT comparing rt-CGM to FST among adults with type 2 diabetes post-hospitalization for DFU. Methods: Ninety-two adults were randomized to rt-CGM (n=45) or FST (n=47). Participants and providers in the rt-CGM arm used CGM for glucose monitoring. Those in the FST arm used only FST for glucose monitoring. We report change in HbA1c between hospital admission and 12-weeks post-discharge, in addition to the 12-week glucose monitoring survey (GMS) score. The GMS is a survey that includes measures of change in patient-reported glucose monitoring satisfaction as a 3-point scale (1) “Worse”, (2) “No Change”, or (3) “Better” during the study period. Results: Participants were mostly male (67%) with a mean age of 53.79 ± 9.96 years old (Table). The median diabetes duration was 15 years and the mean baseline HbA1c was 10.9%. Participants in the rt-CGM arm had a greater mean 12-week HbA1c decrease than those in FST (rt-CGM -2.66 ± 1.77 vs -1.86 ± 1.93 FST, p=.05). Participants in the rt-CGM arm reported a higher 12-week GMS score (rt-CGM -2.39± 0.35 vs -2.15 ± 0.41 FST, p=.02) Conclusion: Compared to FST, rt-CGM improved 12-week post-hospital discharge HbA1c and patient reported glucose monitoring satisfaction scores among people with DFUs. Healing and CGM based glycemic metrics analyses are ongoing. Disclosure J. Flores: None. E. Watson: None. N.Y. Chaudhry: None. N. Soleimanmanesh: None. L. Peng: None. G. Umpierrez: Research Support; Current; Abbott, Dexcom, Inc., Bayer AG. Advisory Panel; Ended; Sanofi-Aventis U.S., Dexcom, Inc. Other - Education grant; Current; Lilly Diabetes, Abbott Diabetes. Advisory Panel; Current; Glycare, Glucotrack. Research Support; Current; Corcept Therapeutics. M. Schechter: None. M. Fayfman: Research Support; Current; Dexcom, Inc., Abbott Diabetes. Funding National Institutes of Health 1R03DK137007-01, Emory Medical Care Foundation Programmatic Support