What does this research mean for the field?

In a predominantly Hispanic pediatric population with atypical diabetes, GCK mutations are the most common cause of Maturity Onset Diabetes of the Young (MODY), accounting for 59% of cases. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to characterize monogenic diabetes, specifically MODY, in a predominantly Hispanic pediatric population.

June 7, 2026Diabetes

2230-P: Profile of Monogenic Diabetes in a Predominantly Hispanic Pediatric Population: Insights from a Single-Center Cohort

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Authors

CACAROLINA M. DE ALMAGRO AGANDREA GRANADOS JVJACQUELYN VERME

Discussion

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Overview

Retrospective chart review characterizes monogenic diabetes in Hispanic pediatric population, suggesting need for genetic testing.

Key Points

This research aims to characterize monogenic diabetes, specifically MODY, in a predominantly Hispanic pediatric population.
Conducted a retrospective chart review from 2016-2025 to identify patients with MODY.
Analyzed patient demographics, genetic testing results, and phenotype-genotype associations from electronic health records.
Evaluated 46 patients with evidence of diabetes atypical for T1D/T2D and confirmed by genetic testing.
GCK mutations were most prevalent, found in 59% of patients, followed by HNF1A (13%), HNF1B (11%), and PDX1 (7%).
The cohort had a mean age of 13 years, was predominantly Hispanic (72%), and 78% reported a family history of diabetes.
Proper identification of genetic forms prevents misdiagnosis; GCK mutations rarely require medication, while others benefit from sulfonylureas.

Cite This Study

ALMAGRO et al. (2026) studied this question.

synapsesocial.com/papers/6a250ae37def13d035e1afa8 https://doi.org/10.2337/db26-2230-p

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June 7, 2026Diabetes

2230-P: Profile of Monogenic Diabetes in a Predominantly Hispanic Pediatric Population: Insights from a Single-Center Cohort

View Full Paper

Ask AI

Bookmark

Authors

CACAROLINA M. DE ALMAGRO AGANDREA GRANADOS JVJACQUELYN VERME

Discussion

Member takes

Overview

Retrospective chart review characterizes monogenic diabetes in Hispanic pediatric population, suggesting need for genetic testing.

Key Points

This research aims to characterize monogenic diabetes, specifically MODY, in a predominantly Hispanic pediatric population.
Conducted a retrospective chart review from 2016-2025 to identify patients with MODY.
Analyzed patient demographics, genetic testing results, and phenotype-genotype associations from electronic health records.
Evaluated 46 patients with evidence of diabetes atypical for T1D/T2D and confirmed by genetic testing.
GCK mutations were most prevalent, found in 59% of patients, followed by HNF1A (13%), HNF1B (11%), and PDX1 (7%).
The cohort had a mean age of 13 years, was predominantly Hispanic (72%), and 78% reported a family history of diabetes.
Proper identification of genetic forms prevents misdiagnosis; GCK mutations rarely require medication, while others benefit from sulfonylureas.

Cite This Study

ALMAGRO et al. (2026) studied this question.

synapsesocial.com/papers/6a250ae37def13d035e1afa8 https://doi.org/10.2337/db26-2230-p

View Full Paper

Ask AI

Bookmark