1357-P: The Hypoglycemia Prevention Program (HPP) for Primary Care: Pilot Clinical Trial

Introduction and Objective: Hypoglycemia, a major cause of morbidity for people with diabetes, is underrecognized in primary care and effective risk reduction tools are underutilized. We developed the HPP, an electronic health record (EHR) integrated toolkit, to increase hypoglycemia prevention. Methods: The HPP Pilot Trial was a pre/post study enrolling adults with diabetes treated with insulin or sulfonylureas at one primary care practice. The intervention, developed through a multistakeholder participatory action process, included: 1) The Patient Hypoglycemia Profile: a pre-visit EHR survey assessing hypoglycemia history and risk factors. 2) The Provider Hypoglycemia Toolkit: EHR alerts and orders populated based on patient responses. 3) A hypoglycemia education handout. The primary outcome was acceptability; exploratory outcomes were changes from baseline in hypoglycemia prevention processes, self-reported hypoglycemia and optional blinded 10-day continuous glucose monitoring. Results: 31 of 35 enrolled patients (88.6%) completed the intervention. The intervention had high acceptability and low patient burden (Table). There was a significant pre/post increase in glucagon prescription from 0% to 29% (p=0.004), and non-significant decreases in hypoglycemia outcomes (Table). Conclusion: A hypoglycemia prevention program designed for primary care is highly acceptable to patients and promising for increasing hypoglycemia risk-reduction and reducing hypoglycemic events. Disclosure S. Pilla: None. C. Snyder: Research Support; Current; Pfizer Inc., Johnson & Johnson. Consultant; Ended; Shionogi & Co., Ltd.