Amyloid-β-laden CSF turns guardian macrophages into collateral damage in Alzheimer's disease

Key Points

• This commentary discusses the implications of amyloid-β's effects on macrophages in Alzheimer's disease by referencing a study on glymphatic failure.
• Analysis of findings from Liu et al. regarding glymphatic failure in specific mouse models.
• Discussion on the role of border macrophages in brain health and Alzheimer's pathology.
• Identifies a correlation between amyloid-β presence and loss of parenchymal border macrophages.
• Suggests that early glymphatic failure could lead to significant macrophage dysfunction in Alzheimer's disease.