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June 7, 2026Diabetes

2136-P: Gestational Circadian Disruption Impairs Glucose Metabolism in Adult Offspring Mice

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Authors

MOMICHAEL I. ORAEBOSIMSMegan SchuppHLHAO LIN

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Overview

Randomized trial investigates the effects of maternal circadian disruption on metabolic health in mice, suggesting significant risks for offspring.

Key Points

  • This study aims to explore how maternal circadian disruption during pregnancy affects the metabolic health of adult offspring.
  • Pregnant C57BL/6J mice were exposed to an 8h light/8h dark cycle during pregnancy.
  • Offspring were assessed for body weight, blood glucose, glucose tolerance, and insulin signaling.
  • A subset faced a high-fat diet to assess metabolic stress response.
  • Male offspring on a short-day cycle showed increased body weight; females did not.
  • Both sexes exhibited elevated blood glucose, impaired glucose tolerance, and insulin resistance.
  • Short-day offspring showed reduced AKT activation and increased hepatic gluconeogenesis.

Cite This Study

ORAEBOSI et al. (2026) studied this question.

synapsesocial.com/papers/6a250b2d7def13d035e1b3d9https://doi.org/10.2337/db26-2136-p
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